The Aim of present work was to formulate Mucoadhesive buccal patches of Venlafexine Hydrochloride .The buccal region of the oral cavity is an attractive target for administration of the drug of Choice for increase bioavailability and prevent first pass metabolism of drug. Venlafexine Hydrochloride patches were prepared using HPMC K15, HPMC K100, PVP K30 Carbopol 934. Formulations were prepared using 23 Factorial Design by YATE’s method. FTIR and DSC data revealed that there is no interaction between Venlafexine Hydrochloride and polymers. The patches were evaluated for their thickness, Uniformity content, folding endurance, weight uniformity, Swelling index, tensile strength and surface pH. In-vitro studies of Venlafexine Hydrochloride -loaded patches in phosphate buffer (pH 6.8) exhibited drug release in the range of 84 to 99% in 8 hrs. Data of In-vitro release from patches were fit in to different mathematical models to explain kinetics. The models used were zero and first-order equations, Higuchi and Korsmeyer-peppas models. The Ex-vivo release study showed that patches could deliver drug to the oral mucosa. The results indicate that the mucoadhesive buccal patches of Venlafexine Hydrochloride may be good choice to bypass the extensive hepatic first pass metabolism with an improvement in the bioavailability of Venlafexine Hydrochloride through buccal mucosa.
Loading....