The aim of present work was to formulate and evaluate novel capsule containing two drugs to treat the prime cause of Gastro Esophageal Reflux Disease (GERD). The system consist of two dosage forms ie-Pantoprazole enteric coated microspheres and Itopride HCl sustained release floating tablet. Pantoprazole microspheres were prepared by spray drying technique while itopride HCl sustained release floating tablet was prepared by direct compression method.Both of the dosage forms were prepared by using 22 full factorial design For microspheres, Independent variables chosen were Drug: Polymer ratio and Feed flow rate whereas independent variables for sustained release floating tablet were concentration of retardant and concentration of gas generating agent. The formulated Microspheres were characterised for Encapsulation Efficiency, Particle size analysis, XRD, SEM studies and In-vitro drug release while sustained release floating tablet was characterised for floating lag time and floating time, micromeritic properties of powder blend, % water uptake, friability test, hardness test, in-vitro drug release study etc.
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