The purpose of this research was to prepare a floating drug delivery system of acyclovir. Floating matrix tablets of acyclovir were developed to prolong gastric residence time and increase its bioavailability. The tablets were prepared by direct compression technique, using polymers such as HPMC K15M, HPMC K100M, Xanthan gum and effervescent agent sodium bicarbonate. Batches were carried out using HPMC K15 M,HPMC K-100 M, Xanthan gum in 1:0.25, 1:0.5, 1:0.75 and 1:1 ratio (drug: polymer) and evaluated. By fitting the data into zero-order, first-order, and Higuchi models, Peppas model we concluded that the release followed Higuchi diffusion kinetics and Peppas model. Storage of the prepared formulations at 40°C/75% relative humidity for 3 months showed no significant change in drug release profiles and buoyancy of the floating tablets. From evaluations we can conclude that natural gum i.e. Xanthan gum containing batches are most promising than HPMC K15 and K100 M. These floating tablets seem to be a promising gastroretentive drug delivery system.
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