In the large-scale high energy physics and astrophysics experiments multi-channel\nreadout application specific integrated circuits (ASICs) are widely used. The ASICs for such\nexperiments are complicated systems, which usually include both analog and digital building\nblocks. The complexity and large number of channels in such ASICs require the proper\nmethodological approach to their design. The paper represents the mixed-signal design flow of\nthe ASICs for high energy physics and cosmic rays experiments. This flow was successfully\nembedded to the development of the read-out ASIC prototype for the muon chambers of the\nCBM experiment. The approach was approved in UMC CMOS MMRF 180 nm process. The\ndesign flow enable to analyse the mixed-signal system operation on the different levels:\nfunctional, behavioural, schematic and post layout including parasitic elements. The proposed\ndesign flow allows reducing the simulation period and eliminating the functionality\nmismatches on the very early stage of the design.
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