Stevens - Johnson syndrome (SJS) is a very rare serious skin and mucous membrane disorder which may be fatal at times induced by immune complex-mediated hypersensitivity reaction. Some drug which act as trigger to cause SJS are oxacarbazepine, allopurinol, penicillin, lamotrigine, sodium valproate, phenytoin, antiretroviral drugs, fluoroquinolones etc. Blisters and sores often seen on the skin and on mucus membranes. A 9 year old girl child weighing 25 kg admitted to the emergency department of a tertiary care teaching hospital with chief complaints of high fever and orogenital, maculopapular rashes, were found over the chest, back, face and eyes. The patient had a history of recurrent seizures 15 days ago and patient was on tablet oxacarbazepine 200 mg OD since 15 days. Thus, a diagnosis of maculopapular, orogenital rashes was oxcarbazepine induced SJS was made by the dermatologist. Steven Johnson Syndrome is a very rare serious life-threatening hypersensitivity reaction which may be fatal at times to choose the alternative drug instead of the suspected drugs and appropriate therapy can enhance the diagnosis of disease. Oxcarbazepine can also be a trigger of SJS in a rare case. Healthcare professionals must be aware of this serious side effect.
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