Based on literature L. esculentum shows action on central nervous system and specially acts on GABAA receptors. The anticonvulsant effects of alcoholic and petroleum ether extracts of tomato in maximum electric shock in mice was tested. Tomato fruits were collected dried, coarsely powdered and latter was soxhelated using petroleum ether and absolute ethanol and air dried to obtain sticky dried extract. Four groups of male Swiss Albino mice (20-30g) were used in this study. Group I animals received the normal saline for 15 days, Group II received standard drug phenytoin (25 mg/kg, p.o.) for 15 days, Group III animals received tomato alcoholic extract (50 mg/kg, p.o.) for 15 days, Group IV animals received tomato petroleum ether extract (50mg/kg, p.o.) for 15 days. On 16th day the electroshock was delivered by using corneal electrodes. The intensity of stimulus was 50-100mA, 50Hz, for 0.2 sec. The animals were observed closely for 2 min and the parameters such as disappearance of the hind leg extensor, tonic convulsion was used as positive criterion. Percent of seizure inhibition relative to control was calculated. The tomato petroleum ether and alcoholic extracts significantly decreased the extension phase and clonic convulsive phase and showed protection in MES induced seizures when compared with phenytoin (p<0.01). The chronic administration of petroleum ether and alcoholic extracts significantly increased the tissue glutathione and decreased the malondialdehyde and protein level in brain (p<0.01). In conclusion, both the extracts of L. esculentum have shown potent anticonvulsant action in MES induced seizures.
Loading....