The main objective of this study was to investigate the protective role of ethanolic extract of Coriandrum sativum L against doxorubicin-induced hepatotoxicity in rats. Twenty Wistar male rats were randomly assigned into four groups. Group 1 served as a normal control. Group 2 received doxorubicin (8mg/kg, i.p) once daily for two days. Group 3 and Group 4 received ethanolic extract of C.sativum (100mg/kg, p.o) & (300mg/kg, p.o) respectively for 14 days and doxorubicin (8mg/kg, i.p) once daily for next two days. On 17th day animals were sacrificed, blood samples were used for biochemical tests whereas liver tissue was isolated for antioxidant and histopathalogical investigations. Rats that received Doxorubicin (8mg/kg, i.p) once daily for two days showed significant (P<0.05) increase in Alkaline Phosphatase (ALP), Bilirubin (BIL), Serum glutamate oxaloacetate transamainase (SGOT), Total protein, and Lipid peroxidation (LPO) levels and decrease in Catalase (CAT), Superoxide dismutase (SOD), Reduced gultathion (GSH) levels as compared to normal control. The animals treated with Coriandurm sativum (100mg/kg & 300mg/kg p.o) showed significant (P<0.05) decrease in ALP, Bilirubin, SGOT, Total protein, & LPO levels and increased CAT, SOD, GSH levels as compared to Doxorubicin group. Histopathological changes showed that DOX caused significant structural changes to liver which was reversed with Coriandrum sativum. Thus, the ethanolic extract of seeds of Coriandrum sativum extract has potential in preventing hepatotoxicity induced by doxorubicin.
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