The present investigation shows the traditional use of Eichhornia crasspies shoot in hepatoprotective agent in combination with CCl4 and Paracetamol in rats. Methods: The ethanolic and aqueous extracts of shoots of Eichhornia crassipes were studied for their hepatoprotective effect. The degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), direct bilirubin and total bilirubin and histopathological studies. Aqueous and ethanolic extracts at a dose level of 250mg/kg and 500mg/kg produce significant hepatoprotection by comparison with control group. Results: Increasing the activity of bilirubin & total bilirubin, they significantly increased the levels of SGOT, SGPT and ALP dose dependent manner and effects of aqueous and ethanolic extracts were comparable to that of standard drug, Silymarin. Conclusion: From this study, it can be concluded that the alcoholic and aqueous extracts of shoot of Eichhornia crassipes an effective hepatoprotective agent.
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