The antiulcer activity of ethanolic extract of the bark of Thespesia populnea was evaluated by using models of acute gastric lesions induced by ethanol induced and pylorus ligation in rats. Animals pretreated with doses of 100mg/kg, 200 mg/kg and 400 mg/kg of ethanolic extract bark of Thespesia populnea by using ethanol induced and pylorus ligation models. It showed significant reduction in lesion index, total affected area and percentage of lesion in comparison with control group in the ethanol induced and pylorus ligation models. These findings indicate that aqueous extract of the bark of Thespesia populnea displays good antiulcer activity, corroborating the folk use of Thespesia populnea preparations, and contributing for its pharmacological validation.
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