In the traditional medicinal practices, several formulations containing Terminalia chebula are used for cognitive improvement. Alzheimer’s disease (AD) is the most common type of dementia disorder of elderly affecting millions of people. The pathophysiology of the disease is complex and involves multiple pathways of neuronal damage. In the present study nootropic acitivity of ethanolic extract of Terminalia chebula was studied in albino rats. In order to evaluate the beneficial effect of Terminalia chebula on learning and memory, an experimental study was conducted in albino rats of either sex. In this study we used a morris water maze apparatus to evaluate the active avoidance learning and memory in mice. Different doses of ethanolic extract of Terminalia chebula (50, 75 and 100 mg/ml) were administered to animals in the test groups. The learning ability and memory recalls were assessed and compared statistically with those of control animals. Our data showed that there is a significant increase in cognitive function was observed in rats receiving various doses 50, 75 and 100 mg/ml. The degree of percent reduction was more in rats receiving 100 mg/ml of extract. Our findings indicate that acute administrations of ethanolic extracts of Terminalia chebula enhance the learning and memory recall ability in rats.
Loading....