The objective of the study was to evaluate the anti-hyperglycemic activity of different solvent extracts of Momordica dioica seeds in both normal and diabetic rats. Diabetes was induced by Streptozotocin (30-50 mg/kg) intraperitoneally, rats which showed glucose >250 mg/100 ml of blood were selected for the study. Metformin was given as a standard drug at a dose of 50 mg/kg orally. OGTT was performed in normal and diabetic rats. The Chloroform and Ethylacetate extracts of M.dioica seeds were prepared and administered orally. The blood glucose levels were estimated by glucose-oxidase method. The hypoglycemic activity of M.dioica seed extracts was observed in normal rats with significant decrease in blood glucose levels, (p<0.0001) at 1 hr, 2 hr and 4 hr. Anti-hyperglycemic activity of the test drug was observed with a significant reduction in blood glucose levels (p<0.0001) at 1 hr, 2hr and 4 hrs. The results suggested that the two different extracts of Momordica dioica seeds may have potent anti-diabetic activity, justifying the use of drug for the treatment of Diabetes mellitus.
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