The present scenario of emergence of multiple drug resistance among clinically isolated organisms has necessitated a search for new antimicrobial substances from other sources including plants. . The present study evaluated the antimicrobial action of Azadirachta indica A. Juss (leaves), Psidium guajava (leaves), Punica granatum (leaves), Syzgium aromaticum (flower buds), Zingiber officinale (rhizomes), Piper nigrum (fruits) extracts on drug resistant pathogens. The ethanol and aqueous extracts of Azadirachta indica A. Juss (Neem)(leaves), Psidium guajava(Guava) (leaves), Punica granatum(Pomegranate) (leaves), Syzgium aromaticum (Clove)(flower buds), Zingiber officinale(Ginger)(rhizomes), Piper nigrum (Pepper) extracts were found to inhibit methicillin sensitive and methicillin resistant Staphylococcus aureus .Pseudomonas spp, Escherichia coli and Salmonella typhi showed sensitivity only to Syzgium aromaticum. All Candida spp. were found to be sensitive to both aqueous and ethanol extracts of Psidium guajava , Punica granatum, Syzgium aromaticum, Piper nigrum. Hence these extracts can be used as antimicrobial agents in new drugs for therapy of infectious diseases in humans
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