The present study was designed to investigate the analgesic activity of ethanolic extract of Nympheaeae stellata thalamus in experimental models. The peripheral and central analgesic activity of ethanolic extract was studied using acetic acid-induced writhing and hot plate method in healthy mice respectively. The extract was used in the doses of 250mg/kg and 400mg/kg of body weight i.p.,morphine hydrochloride (10 mg/kg, i.p.) and acetyl salicylic acid (250mg/kg, i.p.) as standard drugs in the study for comparing analgesic effects for hot plate method and acetic acid induced writhing method respectively. The ethanolic extract of dose 400mg/ kg showed a greater analgesic effect. The results of present study suggested that extracts of N. stellata posses significant analgesic activity in dose dependant manner acting peripherally, feeble effect acting through centrally analgesic activity.
Loading....