The antipyretic activity of Calotropis gigantean linn extract is investigated for its, potential on normal body temperature and yeast-induced pyrexia in albino rats. The whole plant of Calotropis gigantean linn at doses of 200 mg/kg body weight p .o. showed significant reduction in normal body temperature and yeast-provoked elevated temperature in a dose-dependent manner. The effect also extended up to 4 hours after the drug administration. The anti-pyretic effect of whole plant extract was comparable to that of paracetamol (150 mg/kg p.o.,), a standard anti-pyretic agent.
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