Seeds of Butea monosperma (Linn.) Kuntze has been used in Ayurveda and folklore medicine as contraceptive and anthelmintic. However many previous studies have shown its toxicological potential in different forms. The present study was carried out to evaluate repeated dose toxicity of seeds of Butea monosperma in the form of decoction. The test formulation was administered orally at the dose of 1620 mg/kg for 90 consecutive days. Parameters like ponderal changes, biochemical, haematological, bone marrow cytology and histopathology of vital organs were studied. The significant changes observed are increase in MCV, RDW percentage and decrease in MPV and PDW in haematological parameters, while significant increase in blood urea level in biochemical parameter. Histopathologically only change which can be considered as toxic is the marked decrease in the spermatogenesis in the testis. This study revealed that the seeds of Butea monosperma in the form of decoction have severe inhibiting effect on spermatogenesis.
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