The aqueous, methanolic and saponin extracts of Zizyphus nummularia (Z. Rotundifolia) bark were screened for spermicidal activities against human spermatozoa. Extracts were found to produce significant inhibition of sperm motility and cause reduction in viability of sperm cell. Reduction in Hypo-osmotic Swelling (HOS test) indicates the possibility of plasma membrane disintegration. Saponin extract is found to be more active to cause immobilization then aqueous and methanolic extract.
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