Oxidative stress induced by alloxan has been shown to damage pancreatic β-cell and produce hyperglycemia in rats. Acalypha indica leaf extract is being used as a traditionally in the treatment of diabetes. The present study examined the effect of ethanolic extract of Acalypha indica against diabetic rats. An ethanolic extract of Acalypha indica was found to reduce fasting blood glucose in alloxan diabetic rats Diabetic rats treated with 100 mg/kg and 200 mg/kg showed a significant reduction in fasting blood glucose level, expressed as 44.91% and 46.90% change respectively. The maximum reduction (58.80%) was observed with the treatment of AIEExt at 400 mg/kg dose, after 14th days of treatment schedule. Oxidative stress produced by alloxan was found to be significantly lowered by the administration of Acalypha indica ethanolic extract. This was evident from a significant decrease in lipid peroxidation, glutathione peroxidase levels increased in serum as well as glycogen level was found to be increased in liver. The Acalypha indica had exhibited potential antidiabetic and antioxidant activity in alloxan-induced diabetic model through reducing oxidative damage by dose dependent manner.
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