The study was undertaken to evaluate the protective effects of Silymarin and Terminalia chebula against acetaminophen-induced hepatotoxicity. Twenty four male Wistar Kyoto rats were randomly divided into 4 groups of 6 animals each. All the groups were administered with acetaminophen @500mg/kg orally from day 1 to 3. Subsequently, groups 1, 2,3 and 4 were administered with distilled water, silymarin @25mg/kg, T.chebula @125mg/kg and silymarin @25mg/kg + T.chebula @ 125mg/kg, respectively orally from day 4-14. Total proten concentration and alanine transaminase (ALT) activity were determined and histopathology of liver was conducted. The study revealed a significant (p<0.05) decrease in the concentration of total protein and significant (p<0.05) increase in the activity of ALT on 4th day (after induction of toxicity) and there was a reversal of these parameters after treatment on day 14. Histologically, necrotic degeneration, fatty changes and vascular degeneration were noticed in liver in group 1 but the extent of severity was very low in treated groups.
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