A new derivative spectroscopy method was developed and validated for the determination of Dexketoprofen Tromatamol and Dicyclomine HCl in Bulk and binary mixture. The method involved 1st derivative spectroscopy based on the measurement of absorbance at two Zero crossing points, i.e. ZCP of Dexketoprofen Tromatamol (247.0 nm) and ZCP of Dicyclomine HCl (233.0 nm). Beer’s law was obeyed in the concentration range between 9-24 μg/ml for Dexketoprofen Tromataml and 10-60 μg/ml for Dicyclomine HCl. The results of analysis have been validated statistically and by recovery studies. The method was found to be simple, precise, reproducible, less time consuming and economical. Hence it is more suitable for routine analysis of these drugs in combined dosage forms.
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