The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of Meropenem and Sulbactam Sodium in bulk and combined dosage form. The method is based on the simultaneous equations for analysis of both the drugs using 0.1 M KOH as solvent. Meropenem has absorbance maxima at 298 nm and Sulbactam Sodium has absorbance maxima at 260 nm in 0.1 M KOH. The linearity was obtained in the concentration range of 5-70 μg/ml and 2-21 μg/ml for Meropenem and Sulbactam Sodium, respectively. The concentrations of the drugs were determined by using simultaneous equations at both the wavelengths. The mean recovery was 99.5±0.26 and 99.87±0.35 for Meropenem and Sulbactam Sodium, respectively. The method was successfully applied to combined dosage form. The suitability of this method for the quantitative determination of Meropenem and Sulbactam Sodium was proved by validation. The proposed method was found to be simple and sensitive for the routine quality control application of Meropenem and Sulbactam Sodium in combination. The results of analysis have been validated statistically and by recovery studies.
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