The present manuscript describe simple, sensitive, rapid, accurate, precise and cost effective Area under curve spectrophotometric method for the simultaneous determination of Amitryptiline HCl and Chlordiazepoxide in combined tablet dosage form. It involved measurement of area under curve in the wavelength range 231-245 nm and 235-256 nm for AMI and CHLOR respectively. Beer’s law obeyed in concentration range of 3-10 µg/ml for both the drugs. The proposed methods are recommended for routine analysis since they are rapid, simple, accurateand also sensitive and specific. It involves no heating and no organic solvent extraction. These methods were validated for precision, reproducibility, linearity and accuracy as per ICH guidelines.
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