The present manuscript describes simple, rapid, accurate, precise and economical stability indicating assay method for analysis of Citicoline sodium by UV spectrophotometric method. The analysis is based on the stability indicating assay method for using distill water as a solvent. Citicoline sodium has absorbance maxima at 272 nm in distill water. The linearity was obtained in the concentration range of 10-60 μg/ml for Citicoline sodium, respectively. The mean recovery was 100.20±1.16 for Citicoline sodium, respectively. The method was applied for the forced degradation study of this drug. The suitability of this method for the quantitative determination of Citicoline sodium was proved by evaluating different validation parameters. The proposed method was found to be simple and sensitive for the routine estimation of this drug. The results of analysis have been validated by recovery studies.
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