The present manuscript describes simple, sensitive, rapid, accurate, precise and economical Q-absorbance ratio method for the simultaneous determination of Naproxen and Paracetamol in their tablet dosage form. Absorbance ratio method uses the ratio of absorbance at two selected wavelengths, one which is an isoabsorptive point and other being the λ-max of one of the two components. Naproxen and Paracetamol show an isoabsorptive point at 239 nm in 0.1 N NaOH. The second wavelength used is 257 nm, which is the λ-max of Paracetamol in 0.1 N NaOH. The linearity was obtained in the concentration range of 0.5-2.5 μg/ml for Naproxen and 0.83-4.15 μg/ml Paracetamol. The concentrations of the drugs were determined by using ratio of absorbance at isoabsorptive point and at the λ-max of Paracetamol. The method was successfully applied to pharmaceutical dosage form because of no interference. The results of analysis have been validated by recovery studies.
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