A simple, economic, accurate chemical derivatization method was developed for the sertraline Hydrochloride (racemic mixture) in bulk and tablet dosage form. 3-Methyl 2-Benzo Thiazolinone Hydrozone Hydrochloride Monohydrate (MBTH) reagent was used for the chemical derivatization. The maximum absorption was observed at 622.5 nm. The linearity range was found to be 10 - 30 µg/ml. The proposed method was validated. The reports was expressed that the proposed method was found to be simple, precise, accurate and rapid for determination of sertraline Hydrochloride from pure and its dosage forms.
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