A new absorption ratio method was developed and validated for the determination of Ketotifen and Cetirizine Dihydrochloride in tablet. The method involved Q-absorption analysis based on the measurement of absorbance at two wavelengths, i.e. λmax of cetirizine dihydrochloride (230.0 nm) and Iso-absorptive point of both drugs (240.0 nm). Beer’s law was obeyed in the concentration range for KETO and CET was found to be in the range of 4-20 μg/ml for both. The results of analysis have been validated statistically and by recovery studies. The method was found to be simple, precise, reproducible, less time consuming and economical. Hence it is more suitable for routine analysis of these drugs in combined dosage forms.
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