A simple, precise, specific and accurate RP-HPLC method has been developed for the simultaneous determination of Ketotifen and cetirizine dihydrochloride in tablet dosage form. The chromatographic separation was achieved on C18 column using UV detector.The mobile phase consisting of ammonium acetate buffer: acetonitrile (pH 3.5) ratio (60:40) at a flow rate of 1.0 ml/min was used. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness.
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