A simple, precise, accurate, economic and reproducible spectrophotometric method has been developed for simultaneous estimation of Montelukast Sodium (MONTE) and Olopatadine Hydrochloride (OLO) by employing Absorption correction UV spectrophotometric method in 0.1 N NaOH. Wavelength Selected for detection of Montelukast Sodium 346.22 nm and for Olopatadine Hydrochloride 295.18 nm. The linearity was established over the concentration range of 20-40 µg/ml and 10-20 µg/ml for Montelukast Sodium and Olopatadine Hydrochloride with correlation coefficient 0.999 and 0.999, respectively. The mean % recoveries were found to be in the range of 99.76–100.20% and 99.65–100.10% for Montelukast Sodium and Olopatadine Hydrochloride respectively. The proposed method has been validated as per ICH guidelines and successfully applied to the estimation of Montelukast Sodium and Olopatadine Hydrochloride in their Synthetic mixture.
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