A simple, rapid, specific, accurate and precise reverse phase high performance liquid chromatographic method was developed for the estimation of Ilaorazole in Tablet dosage form. C18 (hypersil column) 5mm column having 250Ã?â??4.6 mm id in Isocratic mode with mobile phase containing orthophosphoric acid: methanol (70:30) was used. The flow rate was 1 ml/min and effluents were monitored at 226 nm. The retention time of Ilaprazole is 4.1. The calibration curve was linear over a concentration range from 10 Ã?µg/ml-30 Ã?µg/ml for Ilaprazole.Limit of detection (LOD) and Limit of quantitation (LOQ) were 0.05865 Ã?µg/ml and 0.195503 Ã?µg/ml for Ilaprazole respectively. The developed method was fast, accurate, precise and successfully applied to estimate the amount of Ilaprazole in bulk sample and tablet dosage form so it can be used for regular quality control of the drug.
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