In the present work, a simple, sensitive, specific and validated colorimetric method has been developed for the quantitative estimation of salbutamol sulphate in bulk and pharmaceutical dosage form. Salbutamol sulphate forms a blue coloured chromogen with gibbs reagent in alkaline conditions by electrophilic aromatic substitution. The final stock solution was made to produce 100 μg/ml with distilled water. The λmax was found to be 600 nm for assay. The linearity was found in concentration range of 5-30 μg/ml. The correlation coefficient was found to be 0.9991. The regression equation was found as y=0.0316x-0.0081. The method was validated as per ICH Guidelines.
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