The present work aims to establish a simple spectrophotometric method for quantifying caffeine in active pharmaceutical ingredients. This work was carried out to estimate caffeine bulk by utilizing an area under curve (AUC) method using UV – UV-visible spectrophotometry. For this purpose, the wavelength range between 200-400 nm was selected. Distilled water was used as a solvent throughout the work. Linearity was obtained in the concentration range of 2 to 10 µg/ml (r2 =0.9987) for the method. The developed method was found to be simple, highly sensitive and can be used for routine quality control analysis for spectrophotometric estimation of active pharmaceutical ingredients.
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