Metronidazole is antiamoebic, antiprotozoal, antibacterial agent belonging to the class of nitroimidazoles. Metronidazole is active against a wide variety of anaerobic Protozoal parasites and anaerobic Bacteria, This compound is directly trichomonacidal. It is also active against protozoaes such as trichomonas vaginalis, entamoeba histolytica, giardia lamblia. Metronidazole used in the treatment of intestinal and extraintestinal amoebiasis. Metronidazole used alone or in combination. Metronidazole was first approved by sanofi-aventis for marketing in France and its International Birth Date (IBD) is 29 July 1959. Since that time it has been registered and marketed worldwide. This review covers most recent analytical methods such as various spectroscopic methods, chromatographic methods and other methods for determination of Metronidazole Benzoate and Related Impurity in various pharmaceutical dosage forms and biological matrix were reported.
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