A new simple, sensitive HPLC method was developed and validated for the determination of 3-amino phenol in aripiprazole. Amino impurity was separated on xterra C18 analytical column with buffer consists 0.01 m dipotassium hydrogen phosphate and acetonitrile as mobile phase at a flow rate 1.0 ml/min. The effluent was monitored by UV detection at 210 nm. Column temperature maintained at 40°C, injection volume 10 µl. Calibration plots were linear in the range of LOQ to 150% level, LOQ and LOD were 0.0006 and 0.0002. The high recovery and low relative standard deviation confirm the suitability of the method for routine quality control determination of amino phenol in aripiprazole.
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