Simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of trifluperazine HCl (TPZ) and isopropramide iodide (ISO) in tablet dosage form have been developed. The method was simultaneous equation method; in this method 226.0 nm and 257.0 nm were selected to measure the absorbance of both the drugs at mentioned wavelengths. TPZ shows linearity at 2.5-20 μg/ml and ISO shows linearity in a concentration range of 5-40 μg/ml. Recovery studies range from >99.41% for ISO and >98.93% for ISO in mentioned analytical method i.e. simultaneous equation method. The proposed methods are recommended for routine analysis since it was rapid, simple, accurate and also sensitive and specific (no heating and no organic solvent extraction was required).
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