Two simple, accurate, precise and economical spectrophotometric methods have been developed for the estimation of amlodipine besylate (AML) and clopedogrel bisulphate (CLP) simultaneously in tablet dosage form. Simultaneous method (Method 1) and Absorb (Absorbance) method (Method 2) were used. Beer’s law is obeyed in the concentration ranges of 3-15 μg/ml and amlodipine besylate (AML) and clopedogrel bisulphate (CLP) for simultaneous method as well as absorbance ratio method. The wavelength ranges 279 nm and 289 nm in simultaneous method were selected to determine amlodipine besylate (AML) and clopedogrel bisulphate (CLP), respectively. Wavelength ranges 317 nm (iso-absorptive point) and 230.27 nm (λmax) of (amlodipine besylate) were selected for absorbance ratio (Q absorbance) method. The percent assay for commercial formulation was found to be in the range 99.92% – 100.07% for simultaneous method and 99.85–100.04% for absorbance ratio methods. Recovery was found in the range of for amlodipine besylate (AML) and 98.66-101% for clopedogrel bisulphate (CLP) by simultaneous spectroscopic method and 98.33-100.75% for amlodipine besylate (AML) and clopedogrel bisulphate (CLP) by absorbance ratio method for both the formulations. The results of analysis have been validated statistically and recovery studies confirmed the accuracy and reproducibility of the proposed methods which were carried out according to ICH guidelines.
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