Fexofenadine hydrochloride is a new non-sedating oral antihistaminic which is clinically effective in the treatment of allergic rhinitis. As per Literature survey, there is no UV AUC method has been reported for estimation of fexofenadine HCl in bulk form and in pharmaceutical formulation. Hence an attempt has been made to develop and validate a simple, economic, rapid and accurate method. The linearity for this method was found to be in the range of 40-90 μg/ml. The calibration curve was drawn by plotting graph between AUC and concentration. Coefficient of correlation was found to be 0.9934. The regression of the curve was Y = 0.0093x + 0.9706. The lower limit of detection and the limit of quantification were found to be 6.87 μg/ml and 20.84 μg/ml respectively. The percentage recovery was found to be 94.99±0.3269.
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