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Inventi Rapid: Pharm Analysis & Quality Assurance

Articles

  • Inventi:prpaqa/15433/21
    Determination of Pyridine-4-Aldehyde as a Genotoxic Impurity in Donepezil hydrochloride by HPLC
    01-Jul-2015 Research 2015 : July-September
    Ravi Kalgutkar*, Ramakrishna K, Shobha Shenoy, Pawanjeet J Chhabda, Srinivasarao V

    A simple liquid chromatographic method has been developed for the determination of Pyridine-4-aldehyde in donepezil hydrochloride drug substance. The method was validated as per ICH guideline in terms of LOD, LOQ, Method precision, accuracy and specificity. The LOD and LOQ values were found to be 7 ppm (7 µg/ml) and 21 ppm (21 µg/ml) respectively.

    How to Cite this Article
    Ravi Kalgutkar, Ramakrishna K, Shobha Shenoy et al. Determination of Pyridine-4-Aldehyde as a Genotoxic Impurity in Donepezil hydrochloride by HPLC. Inventi Rapid: Pharm Analysis & Quality Assurance, 2015(3):1-4, 2015.
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