The present work deals with development and validation of two rapid, precise and accurate spectrophotometric methods for the estimation of midodrine HCl in bulk and tablet dosage form. Method A is the absorbance maxima method where absorbance maxima of the drug was recorded at 289 nm. Method B is area under the curve in which wavelength range 285-295 nm was selected for estimation of midodrine HCl. Linearity was observed in the concentration range 10-90 µg/ml for both the methods (r2=0.9994 for method A and method B). The results of analysis were validated statistically, which confirmed the accuracy and reproducibility of the methods. Both the methods were found to be simple, precise and accurate and can be employed for routine quality control analysis of midodrine HCl in bulk as well as in its solid dosage form.
Loading....