The present work deals with development and validation of two precise and accurate spectrophotometric methods for the estimation of Levamisole HCl in bulk and tablet dosage form. Method A is the absorbance maxima method where an absorbance maximum of the drug was recorded at 213 nm. Method B is area under the curve in which wavelength range 208-218 nm was selected for estimation of Levamisole HCl by using Co-solvent method (methanol as a starting solvent and further water as a solvent). Linearity was observed in the concentration range 2-14 µg/ml for both the methods (r2 = 0.999 for method A and r2 = 0.9991 for method B). The results of analysis were validated statistically, which confirmed the accuracy and reproducibility of the methods. Both the methods were found to be simple, precise and accurate and can be employed for routine quality control analysis of Levamisole HCl in bulk as well as in its solid dosage form.
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