A simple, sensitive, precise and accurate new UV-visible spectrophotometric method has been developed for estimation of ibuprofen and carisoprodol in synthetic mixture. The method was based on employing absorption ratio method for analysis of both drugs. The proposed method employs the derivatization of carisoprodol by reagent 1,2-Naphthoquinone-4-sulfonic acid sodium salt in the presence of borate buffer at optimize condition. Linearity range was observed in the concentration range of 40-90 ?g/ml for carisoprodol and 80-180 ?g/ml for Ibuprofen. The method involved simultaneous analysis based on the measurement of absorbance at two wavelengths, i.e., iso-absorptive point of both drugs (260.60 nm) and ?max of ibuprofen (265.0 nm). The method was validated statistically and recovery study was performed to confirm the accuracy of the method.
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