A simple gas chromatographic method has been developed for the determination of methyl methane sulfonate, ethyl methane sulfonate and isopropyl methane sulfonate in emtricitabine drug substance. The method was validated as per ICH guideline in terms of LOD, LOQ, method precision, accuracy and specificity. The LOD and LOQ values were found to be 0.5 ppm (0.5 µg/g) and 1.5 ppm (1.5 µm/g) respectively.
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