A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of aripiprazole and escitalopram oxalate in synthetic mixture using simultaneous equation method. In this spectroscopic method, 255.00 nm and 238.00 nm wavelengths were selected for measurement of absorptivity. Both the drugs show linearity in a concentration range of 5-30 μg/ml and 15-75 μg/ml at their respective λmax. Accuracy, precision and recovery studies were done by QC samples covering lower, medium and high concentrations of the linearity range. The relative standard deviation for accuracy, precision studies were found to be within the acceptance range (<2%). The limit of determination was 0.129 and 0.223 μg/ml aripiprazole and escitalopram oxalate, respectively. The limit of quantification was 0.392 and 0.677 for aripiprazole and escitalopram oxalate, respectively. Recovery of aripiprazole and escitalopram oxalate was found to be 100.66 % and 100.70 % respectively confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since it is rapid, simple, accurate, sensitive and specific by no heating and no organic solvent extraction.
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