A simple accurate and precise Q-absorbance ratio spectrophotometric method has been developed for estimation of cefepime hydrochloride and sulbactam sodium in injection dosage form. The iso-absorptive point was found to be 240 nm. The beer-lambert law followed in concentration range 4-32 μg/ml at 240 nm for cefepime hydrochloride and in 2-16 μg/ml at 263 nm sulbactam sodium respectively. The method was validated statistically as per ICH guidelines. The method showed good reproducibility and recovery with % RSD less than 2.
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