Aim of this research was to develop a simple, precise, accurate and reproducible absorbance ratio method for estimation of amiodaroone HCl and ranolazine in combination of synthetic mixture in 1: 10 ratios and validate it as per ICH guidelines. Methanol selected as a solvent for estimation of amiodarone HCl at 258.62 nm and for ranolazine at 273.00 nm in linearity range 1-20 µg/ml and 10-200 µg/ml respectively. The correlation coefficient (r2) for amiodarone HCl was 0.9998 and for ranolazine 0.9996. The mean % recovery was found to be in range of 99.77%-101.22% for amiodarone HCl and 99.90%-100.58% for ranolazine. The result of analysis has been validated statistically and recovery studies recommended for routine since it is rapid, simple, accurate, sensitive.
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