The main objective of the study was to develop and validate simple, sensitive, precise and cost effective method for the estimation of canagliflozin in bulk and pharmaceutical dosage form as per ICH guidelines. Two simple spectrophotometric methods have been developed for determination of canagliflozin from tablet dosage form. First method was area under curve method where area under curve in the range of 275.2 - 304.8 nm was selected for the analysis. Second method was first order derivative spectrophotometric method in which absorbance was measured at λmin= 273.2 nm, λmax = 311.6 nm and Zero cross = 289.84 nm. Linearity for detector response was observed in the concentration range of 10-35 µg/ml at the λmax= 290.6 nm. The accuracy and precision of the methods were determined and validated statically. Both the methods showed good reproducibility and recovery with % RSD less than 2. The proposed methods were found to be rapid, reliable, specific, precise and accurate and hence can be successfully applied for the routine analysis of canagliflozin in bulk and pharmaceutical dosage forms.
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