A simple, accurate, reproducible, precise and economic reverse phase high performance liquid chromatographic method was developed for simultaneous estimation of clopidogrel bisulphate and irbesartan in synthetic mixture. Column used were phenomenex C18, 250 mm x 4.6 mm, 5 μm particle size in isocratic elution mode with mobile phase acetonitrile:0.2 M potassium dihydrogen orthophosphate (68:32 v/v) and pH adjusted to 4.0 with ortho phosphoric acid was used. The flow rate was 1.0 ml/min and absorbance of component was measured at 220 nm. The retention times of clopidogrel bisulphate and irbesartan were found to be 8.94 and 4.15 min, respectively. Linearity for both drugs clopidogrel bisulphate and irbesartan was in the range of 10-250 μg/ml with correlation coefficient values 0.9998 and 0.9997, the percentage recovery obtained was 99.26 and 99.56 %, respectively.
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