A simple, efficient, precise and accurate spectroscopic method has been developed and validated for quantitative estimation of ketoconazole in bulk and tablet dosage form. Ketoconazole standard solution was scanned in the UV rang (400-200 nm) in a 1 cm quartz cell in a double beam UV spectrophotometer. The max of ketoconazole was 277 nm. The method obeys beers law in the concentration range from 50-250 μg/ml. The correlation coefficient was found to be 0.9992 and regression of the curve was found y=0.0023x + 0.0172 with excellent recovery 99-101%. Limit of detection and limit of quantitation were found to be 0.19249 mg/ml and 0.58332 mg/ml respectively. The method was validated for several parameters like accuracy, precision as per ICH guidelines. Value of % RSD and % recovery was found satisfactory, hence that the proposed method is precise, accurate and economical hence can be used for routine analysis.
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