The main goal of this review is to provide overview on the different method development techniques that are necessary to analyse the antiretroviral drugs. Different analytical techniques are to ensure the availability of safe and effective dosage forms of drugs to consumer’s quality assurance and quality control of pharmaceutical substances and formulations are essential. Anti-retroviral drug are used in the treatment of patients suffering from AIDS. The paper describes a selective, sensitive and robust method for determination of Nucleoside reverse transcriptase inhibitors (NRTIs), Non-nucleosid reverse transcriptase inhibitors (NNRTIs), Protease inhibitors (PIs), Integrase inhibitors (INSTIs), Chemokine receptor antagonists (CCR5 antagonists) by UV method, HPLC, UPLC, LC-MS/MS technique. The validated method can be useful in determining of antiretroviral drugs for therapeutic drug monitoring and in high throughput clinical studies.
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