The article describes a simple, sensitive, rapid, accurate and precise spectrophotometric method for the determination of gliclazide in bulk and pharmaceutical dosage forms by utilizing area under curve (AUC) method. The new method is area under curve method for the analysis of gliclazide using methanol as solvent for the drug. Gliclazide has absorbance maxima at 228.20 nm at area under curve wavelength range of 217.40-236.80 nm. Gliclazide obeys Beer’s law in concentration range 2-10 µg/ml. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.31 µg/ml and 0.92 µg/ml respectively. The percentage recovery of the drug for the proposed method ranged from 98.72-100.5% indicating no interference of the tablet excipients. The method developed was validated for linearity, precision, accuracy, LOD, LOQ as per ICH guidelines. The result demonstrates that proposed method is accurate, precise and reproducible while being simple and rapid too for the determination of gliclazide in tablet dosage form.
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