A simple stability indicating HPLC method was developed and validated for the estimation of ofloxacin and racecadotril in tablet dosage form. Optimized method was developed using discovery C8 column (250×4.6 mm, 5µ) at 295 nm using a mobile phase composition of acetonitrile and orthophosphate buffer of pH 4.8(55:45 v/v) at a flow rate of 1 ml/min. Injection volume was selected to be 10 µl and run time of 7 minutes as analytes were separated around 2.7 and 3.7 minutes respectively. Analytical method was found linear over a range of 25-150 µg/ml for both ofloxacin and racecadotril. Percentage recovery was found to be 98.55-98.85%. Stability studies for the developed method in different conditions were also performed and method was validated according to ICH guidelines and successfully applied for the estimation of drugs in tablet dosage form.
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