Two simple UV-spectrophotometric methods have been developed for estimation of trazodone HCl (TZH) in bulk and pharmaceutical formulation using zero order UV-spectrophotometry absorbance method (Method I) and zero order UV-spectrophotometry method using area under curve technique (Method II). Water was used as solvent for both methods. In water, trazodone hydrochloride showed λmax at 246.0 nm. AUC was integrated between two wavelengths 235.20 nm – 256.60 nm. In both methods trazodone showed linearity in the concentration range of 05-35 µg/ml (r2>0.99). Proposed methods were applied for oral dosage and amounts of TZH estimated by Method I were found to be 99%, by Method II were found to be 98.80% respectively. Both these methods were validated statistically and by recovery experiments.
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